Right dosage of Acetaminophen and treatment for over dosage problems

Fioricet contains Acetaminophen.

Blue Fioricet Online
Blue Fioricet Online

Acetaminophen is a pain reliever and also treats many other types of pain ailments. The medicine still has its own set of drawbacks which can cause permanent damage to your liver or other health problems, if not taken in right doses. This article would help you know the right dosage of Acetaminophen and the effects of overdosing along with the treatment used to treat overdosing problem.

You need to store the medicine in room temperature and keep it away from moisture and heat. Stop using Acetaminophen can contact your doctor if

  1. The fever persist even after 3 days of its consumption
  2. The pain exist after seven days of using the medicine
  3. You develop skin rash, redness, swelling or constant headache.
  4. If the symptoms turn severe or you develop some other new symptoms.

What if you missed a dose?

Since Acetaminophen is used as required, you do not need to maintain a dosing schedule. If you are using the medicine regularly, you can always take the dose you missed as soon you come to know. Do not take extra dose of medicine to make up your missing dose.

What if you overdose?

You need to immediately call emergency medical help as overdose can be fatal. The initial symptoms of overdose of Acetaminophen can be vomiting, sweating, stomach pain, appetite loss, weakness or confusion.

Dosing Information

Dose for Adults – for fever

Adolescents and adults having body weight 50 kg or more

1000mg after every 6 hours or

650 mg every 4 hours

With a single dose of 1000 mg per day, you can take maximum 4000mg per day

Adolescents and adults having body weight less than 50 kg

15 mg after every 6 hours or

12.5 mg after every 4 hours

No adjustment of dose is necessary when changing between IV and oral Acetaminophen dosing in adolescents and adults. The highest dose of Acetaminophen per day entirely depends on all courses of administration like rectal, oral and intravenous and all types of products comprising of Acetaminophen.

Overdose of Acetaminophen and treatment

Overdose of Acetaminophen can affect your liver; many people are using Acetaminophen for pain relief or to reduce fever. Acetaminophen is an active ingredient in many other OTP products like the ones used for sleeping remedies, flu, cold etc., it is also an active ingredient in many pain relievers.

Overdose of Acetaminophen results in abnormal functioning of liver, liver failure, increased liver enzymes or even death. Acetaminophen leaves residues in your liver that are highly toxic and liver needs help to flush out the toxins from the body.

Acetaminophen overdose is a serious problem, which needs proper treatment. Treatment should be given to the patient immediately. Patients are treated by giving medicine like activated charcoal to absorb Acetaminophen that is still present in your stomach. Activated charcoal makes the patient vomit. This helps cleaning of gastric lavage and flush out Acetaminophen.

Sometimes antidote medicine is given to control and stop the effects of overdosing.

Acetaminophen drug interactions with different drugs explained

Fioricet contains a combination of acetaminophen, butalbital, and caffeine Acetaminophen is a pain reliever and fever reducer.

Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Fioricet is used to treat tension headaches that are caused by muscle contractions.

If you are using any narcotic drug, it is always better to know about its drug interactions with other products. This can help you use the drug safely and avoid using the products or medicines that have adverse effects when used with your drug.

A product that can interact with Acetaminophen is ketoconzole. This medication can interfere with some laboratory test resulting in incorrect lab results. Let your laboratory personnel know that you are using this drug.

Drug Interactions

Acetaminophen with Isoniazid

The information shared is generalized and not given as a medical advice. Consult your doctor before using or discontinuing any drug or starting any treatment.

Medical warning

Moderate risks. These drugs can results in some risks when consumed together. Contact your doctor for detailed information.

How the drug interaction occurs

Isoniazid can affect how the liver processes the medicine Acetaminophen.


The quantity of metabolite of Acetaminophen in the liver can increase or cause liver damage.

Let your doctor know that you are using these two medicines together. Your health care provider might suggest you to try some other pain reliever while consuming Isoniazid.  Also inform your doctor if you notice any signs of liver problems like nausea, vomiting, dark urine, yellowing of eyes or abdominal pain. Do not change, start or stop the current dosage on your own without talking to your doctor.


Acetaminophen with Busulfan

Medical warning

Moderate risks. These drugs can lead to some risks when used together. Contact your health care provider for detailed information.

How the drug interaction occurs

Acetaminophen can slow down the speed of your body to removing busulfan.

What can happen?

It might take a long time for your body to eliminate busulfan.

What should you know about the interaction (Acetaminophen with Busulfan)?

Inform your doctor that you are using the two medicines together. Your doctor might advise you to stop using Acetaminophen for three days prior to busulfan therapy and a few days after the busulfan therapy. If you are not sure whether your medicine consists of Acetaminophen, check with your pharmacist.

If you notice any signs like chills, fever, sore throat abdominal pain, yellowing of skin or eyes, vomiting, depression, mood changes, anxiety, hallucinations, irregular heartbeat, confusion and muscle cramps. Contact your doctor immediately.

Acetaminophen- Selected Anticoagulants

Medical warning

Moderate risks. These drugs can lead to some risks when used together. Contact your health care provider for detailed information.

How the drug interaction occurs

Acetaminophen when taken regularly can affect the ability of your body to make clots.

What can happen?

You may notice an increased bleeding including bleeding gums, nosebleed, dark stools and unusual bruising.

What should you know about the interaction?

Let your doctor know that you are using the two medicines together, the dose of Acetaminophen you use and how frequently you use Acetaminophen. You doctor may ask you that he wants to check the INR values closely. If you have stopped taking Acetaminophen, let your doctor know about it. If you observe any signs of nose bleeding, unusual bruising etc., immediately contact your doctor.

What do you need to know about Acetaminophen overdose?

Acetaminophen is fever reducer and pain reliever. It is used for treating many conditions like colds, backache, fevers, muscle aches, headache, toothaches and arthritis. Acetaminophen causes damage to the liver so let us understand how to protect you.

Acetaminophen is very popular today and many people use it today as OTC drug for reducing fever or as a pain reliever. Acetaminophen is present as an active ingredient in many remedies used as OTC for sleeping, flu and cold. It is also present as active ingredient in various pain relievers or OTC drugs like Excedrin, Tylenol and brands that are prescribed like Percocet or Vicoden.

What are the risks associated with Acetaminophen? Most people feel that hepatitis or alcohol consumption is the major reasons that lead to liver failure. Well, that is not true. Acetaminophen overdose becomes the leading cause of damage to the live mostly in United States. This can result in liver failure, increased liver enzymes, abnormal function of the liver and even death. There are toxic residues left by Acetaminophen in your liver, and your liver needs help in removing the toxic residues from the body. These residues can pile up over a period of time if the liver doesn’t get the help that it needs to do its job. Acetaminophen also leads to acute failure of liver.

Some people who try to combine Acetaminophen and alcohol to commit suicide can lead to dangerous effect like liver failure and it can be fatal as well if left untreated right away. When a person with overdose of Acetaminophen, he/ she needs to hospitalize immediately and this can help saving the patient’s life.

In order to avoid the risk factors associated with Acetaminophen, the most important thing you should remember is that make sure you read the entire information given on the label and follow instructions mentioned for dosing carefully. Do not exceed the recommended dose, even if you feel you need it. With Acetaminophen there is very less room for error so being alert. On the label you will find the instructions regarding the duration for which you can take the medicine. Make sure  you follow this precaution strictly. Ideally you should not take the medicine for more than ten days and ask for medical help in any problem occurs.

Also read the labels of the medicines you’re taking carefully to avoid doubling up  the recommended dose in order to avoid Acetaminophen overdose. Do not combine alcohol with Acetaminophen as this elevates the load of toxins on your liver. Some of the symptoms of Acetaminophen overdose that you might observe are flu. In such cases you might feel you are having normal flu, whereas this can be because you are taking Acetaminophen since past many days, it is better to consult your doctor immediately to avoid further complications. It can save your life. It is always better to be safe so avoid taking overdose of Acetaminophen and follow the instructions on the label carefully to avoid risks that can be fatal.

FeverAll® Recommended Doses

FeverAll® Recommended Doses

Age Infants’
80 mg
120 mg
Jr. Strength
325 mg
Under 6 months Do not use Do not use Do not use
6 – 11 months 1 suppository every 6 hours. Maximium 4 doses in 24 hours. Do not use Do not use
12 – 36 months 1 suppository every 4 to 6 hours. Maximum of 5 doses in 24 hour period. Do not use Do not use
3 – 6 years 1 suppository every 4 to 6 hours. Maximum of 5 doses in 24 hours. Do not use
6 – 12 years 1 suppository every 4 to 6 hours. Maximum 5 doses in 24 hours.
12 years & over 2 suppositories every 4 to 6 hours. Maximum of 6 doses in 24 hours.

Important Safety Information

Acetaminophen Suppository for Babies

FeverAll Infants’ 80 mg Acetaminophen Suppositories

Active Ingredients

Acetaminophen80 mg, Pain Reliever/Fever Reducer

Inactive Ingredients

Glycerol Monostearate , Hydrogenated Vegetable Oil , Polyoxyethylene Stearate , Polysorbate 80

Nutrition Facts
Serving Size : 1 Suppository
Amount Per Serving % Daily value*

Liver warning:  This product contains acetaminophen.  Severe liver damage may occur if your child takes:

  • More than 4 doses in 24 hours, which is the maximum daily amount for ages 6 to 11 months
  • More than 5 doses in 24 hours, which is the maximum daily amount for ages 12 to 36 months
  • With other drugs containing acetaminophen

For rectal use only

FeverAll Infants' 80 mg Acetaminophen Suppositories

Do not use

  • If you are allergic to acetaminophen
  • With any other drug containing acetaminophen (prescription or nonprescription).  If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist

Ask a doctor before use if

  • The child has liver disease
  • The child is taking the blood thinning drug warfarin

Stop use and ask a doctor if

  • Fever lasts more than 3 days (72 hours), or recurs
  • Pain lasts more than 3 days or gets worse
  • New symptoms occur
  • Redness or swelling is present in the painful area

These may be signs of a serious condition.

Keep out of reach of children.  If swallowed or in case of overdose, get medical help or contact a Poison Control Center right away.  Quick medical attention is critical in case of overdose for adults and for children even if you do not notice any signs of symptoms.

Temporarily:  Reduces fever.  Relieves minor aches, pains and headache.

  • Ages 6-36 months
  • Doctor recommended
  • This product does not contain directions or warnings for adult use
  • Do not use more than directed
  • Remove wrapper
  • Carefully insert suppository well up into the rectum
Dosing Chart
Age Dose
Under 6 months Do not use unless directed by a doctor
6 to 11 Months Use 1 suppository every 6 hours
(maximum of 4 doses in 24 hours)
12 to 36 Months Use 1 Suppository every 4-6 hours

(maximum of 5 doses in 24 hours)

Other information

  • Store at 2°-27°C (35°-80°F)
  • Do not use if imprinted suppository wrapper is opened or damaged

©Actavis Mid Atlantic LLC


Acetaminophen Suppository

WARNING: One ingredient in this product is acetaminophen. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. If you have liver problems, consult your doctor or pharmacist for a safe dosage of this medication. Daily use of alcohol, especially when combined with acetaminophen, may increase your risk for liver damage. Avoid alcohol. Check with your doctor or pharmacist for more information. Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting, stomach/abdominal pain, extreme tiredness, or yellowing eyes/skin.

Acetaminophen is an ingredient found in many nonprescription products and in some combination prescription medications (such as pain/fever drugsor cough-and-cold products). Carefully check the labels on all your medicines because they may also contain acetaminophen. Ask your pharmacist about using those products safely. Get medical help right away if you have taken more than 4000 milligrams of acetaminophen a day, even if you feel well.


USES: This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu achesand pains) and to reduce fever.

HOW TO USE: See also Warning section.Use this product rectally as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.First, unwrap 1 suppository. Lie down on your left side with right knee bent. If giving to a child, the child may lie on the side or flat on the back. Gently push the suppository into the rectum with your finger. After inserting the suppository, if necessary, hold the buttocks together for 30 to 60 seconds to keep the suppository in place. Remain lying down for a few minutes, and avoid having a bowel movement for an hour or longer so the drug will be absorbed. The suppository is for rectal use only.Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.Do not use more than recommended. Do not use this medication for fever for more than 3 days unless directed by your doctor. For adults, do not use this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, ornausea/vomiting), consult the doctor promptly.Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.

SIDE EFFECTS: See also Warning section.This drug usually has no side effects. If you have any unusual effects, contact your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergicreaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: See also Warning section.Before using acetaminophen, tell your doctor or pharmacist if you are allergic to it; or if you have any otherallergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this product, tell your doctor or pharmacist your medical history, especially of: liver disease, regular use/abuse of alcohol.Tell your doctor if you are pregnant before using this medication.Acetaminophen passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.Some products that may interact with this drug include: “blood thinners” (such as warfarin), isoniazid, ketoconazole.This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

OVERDOSE: This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, increasedsweating, yellowing eyes/skin, dark urine, severe stomach/abdominal pain, extreme tiredness.

NOTES: Acetaminophen does not cause the stomach and intestinal ulcers that NSAIDs such as aspirin, ibuprofen, and naproxen may cause. However, acetaminophen does not reduce swelling (inflammation) like the NSAIDs do. Consult your doctor for more details and to see which medication might be right for you.

MISSED DOSE: If you are using this medication on a regular basis and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature away from heat. If the room temperature is above 80 degrees F (27 degrees C), then store the medication in the refrigerator. Do not freeze. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy.



This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy.


An open, randomized, comparative study was conducted. Subjects with painful symmetric neuropathy in the lower limbs and mean pain-intensity score > or = 4 on a numeric rating scale were eligible. Subjects were randomized to receive either tramadol (37.5 mg)/acetaminophen (325 mg) or gabapentin (300 mg) for 6 weeks. After 2 weeks of the titration period (1200 mg/day for gabapentin and three tablets/day for T/A), the doses were maintained if the pain was relieved. The primary efficacy outcome was a reduction in pain intensity. Secondary measures evaluated a pain relief scale, a Brief Pain Inventory, a 36-item Short Form Health Survey, average pain intensity and sleep disturbance.


One hundred and sixty-three subjects (T/A 79; gabapentin 84) were included. At the final visit, the mean doses were 1575 mg/day for gabapentin and 4.22 tablets/day for T/A. Both groups were similar in terms of baseline pain intensity (mean intensity: T/A 6.7 +/- 1.6; gabapentin 6.3 +/- 1.6, P = 0.168). At the final visit, the mean reductions in pain intensity were similar in both groups (T/A -3.1 +/- 2.0; gabapentin -2.7 +/- 2.1, P = 0.744). Both groups had similar improvements in every Short Form Health Survey category and Brief Pain Inventory subcategory, and in the mean pain relief scores.


This study suggests that the T/A combination treatment is as effective as gabapentin in the treatment of painful diabetic neuropathy in patients with Type 2 diabetes.

How can I safely give acetaminophen to my child?

A: You can safely give acetaminophen to infants, children, and teenagers if you

  • Check the active ingredients in the other medicines that your child is taking (or that your child may take) to make sure they don’t contain the active ingredient acetaminophen. Your child should never be taking more than one medicine containing acetaminophen at a time.
  • Read all the information given by your child’s doctor and follow directions.
  • Read the information on the OTC “Drug Facts” label or on the prescription label and follow directions.
  • Choose the right medicine based on your child’s weight and age. On OTC medicines, the Directions section of the “Drug Facts” label tells you:
    – if the medicine is right for your child
    – how much medicine to give
    – how many hours you must wait before giving another dose
    – when to stop giving acetaminophen and ask a doctor for help

If a dose for your child’s weight or age is not listed on the label, or you can’t tell how much to give, ask your pharmacist or doctor what to do.

  • Use the measuring tool that comes with the medicine. It will give the exact dose. If you don’t have the right measuring tool, ask a pharmacist.
  • Don’t use a spoon that’s meant to be used for cooking or eating. A spoon should not be used to measure medicine because it may give the wrong amount.
  • Never give more than one medicine that contains acetaminophen. If you give more, it could harm your child.

How can I safely take acetaminophen?

A: Follow this advice to take acetaminophen safely:

  • Read all the information given to you by your doctor and follow directions.
  • Read the information on the OTC “Drug Facts” label or on the prescription label and follow directions.
  • Be sure you understand the following:
    – the dose, which is how much acetaminophen you can take at one time
    – how many hours you must wait before taking another dose of acetaminophen
    – how many doses of acetaminophen you can take safely each day
    – when to stop taking acetaminophen and ask a doctor for help
  • Never take more than directed, even if your pain or fever isn’t any better. Taking more acetaminophen than directed can put you at risk for liver damage.
  • Never take more than one medicine that contains acetaminophen. Check the active ingredients of all your medicines to make sure you are taking no more than one medicine containing acetaminophen at a time.